Expresión de búsqueda: ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO 
Descriptores Encontrados: 1
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Descriptor Inglés:   Alpha-Ketoglutarate-Dependent Dioxygenase FTO 
Descriptor Español:   Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato 
Descriptor Portugués:   Dioxigenase FTO Dependente de alfa-Cetoglutarato 
Sinónimos Inglés:   AlkB Homolog 9 Protein
Alpha Ketoglutarate Dependent Dioxygenase
Alpha Ketoglutarate Dependent Dioxygenase FTO
Alpha-Ketoglutarate-Dependent Dioxygenase
Dioxygenase, Alpha-Ketoglutarate-Dependent
FTO, Alpha-Ketoglutarate-Dependent Dioxygenase
Fat Mass and Obesity Associated (FTO) Protein
Fat Mass and Obesity Associated Protein  
Categoría:   D08.811.074.062.968
D08.811.682.662.582.242
D08.811.682.690.416.139.992
Definición Inglés:   A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS. 
Nota Histórica Inglés:   2017 
Calificadores Permitidos Inglés:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número del Registro:   56463 
Identificador Único:   D000071516 

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